During the past several decades, advancement in lifestyle reduce the consumption of Indian spices due to elevated intake of fast food, which is directly associated with breast cancer risk. The relationship between consumption of Indian spices and breast cancer may be affected by stage of life in which a women gain weight. The correlation among consumption of Indian spices and breast cancer incidences in menopausal women of Ajmer municipal area has been examined in the present study. A population based study was conducted on 125 menopausal women of Ajmer municipal area, who had regular menstrual cycle fewer than 40 days apart, having breast cancer and 130 menopausal women not having breast cancer. Extent of consumption of Indian spices was estimated with a validated food frequency questionnaire. In order to create dose response association in menopausal women, consumption of Indian spices was included as a categorical indicator variable in questionnaire. Logistic regression was used to estimate odd ratio and its 95 percent confidence interval for breast cancer. After taking the characteristics for age, BMI, number of children, breast feeding period, age at menarche, it was found that the low consumption of Indian spices was significantly associated with breast cancer risk in premenopausal women.