INTERNATIONAL RESEARCH JOURNAL OF SCIENCE ENGINEERING AND TECHNOLOGY

( Online- ISSN 2454 -3195 ) New DOI : 10.32804/RJSET

Impact Factor* - 6.2311


**Need Help in Content editing, Data Analysis.

Research Gateway

Adv For Editing Content

   No of Download : 201    Submit Your Rating     Cite This   Download        Certificate

BIOSYNTHESIS OF LYCOPENE (A NEUTRACEUTICAL COMPOUND) FROM MICROBIAL CELLS AND ITS APPLICATION

    1 Author(s):  RAJESH K. SRIVASTAVA

Vol -  7, Issue- 2 ,         Page(s) : 69 - 74  (2017 ) DOI : https://doi.org/10.32804/RJSET

Abstract

Metabolically engineered Escherichia coli have been reported to produce the recombinant lycopene with good yields which is being dependent upon inocula state. Lycopene biosynthesis in Escherichia coli has been constructed by the corresponding single, double and triple gene knockouts and final lycopene yield are reported up to 260 mg/l for 60 h. Improving cells and central components (e.g. assessing cell physiology) of metabolic engineering has been developed a new tools to take advantage of the opportunities arising from the availability of whole-genome sequence information. Cellular phenotype is a manifestation of gene expression levels, metabolic demand, resource availability

  1. Kim, S.W., Kima, J-B., Ryu, J.M., Jung, J.K., Kim, J.H., 2009. High-level production of lycopene in metabolically engineered E. coli. Process Biochemistry,  44 (8): 899-905.
  2. Sandmann, G., 2001.Genetic manipulation of carotenoid biosynthesis: strategies, problems and achievements Trends Plant Sci.,  6(1):14-7.
  3. Alper, H., Stephanopoulos, G., 2004. Metabolic engineering challenges in the post-genomic era. Chemical Engineering Science,  59(22–23) : 5009-5017.
  4. Alper, H, Jin Y.S.,.. Moxley J.F., Stephanopoulos, G., 2005. Identifying gene targets for the metabolic engineering of lycopene biosynthesis in Escherichia coli. Metabolic Engineering, 7, ( 3): 155-164.
  5. Alper, H., Stephanopoulos, G., 2007. Global transcription machinery engineering: A new approach for improving cellular phenotype. Metabolic Engineering, 9(3) Pages 258-267
  6. Kang, M.J., Lee, Y.M., Yoon, S.H., Kim, J.H., Ock, S.W., Jung, K.H., Shin, Y.C., Keasling, J.D, Kim, S. W. 2005. Identification of genes affecting lycopene accumulation in Escherichia coli using a shot-gun method. Biotechnol Bioeng.  Sep 5;91(5):636-42.
  7. Shen, H.J., Hu, J.J., Li, X.R., Liu, J.Z., 2015. Engineering of Escherichia coli for Lycopene Production Through Promoter Engineering. Curr Pharm Biotechnol. ;16(12):1094-103.
  8. Yamano, S, Ishii, T., Nakagawa, M., Ikenaga, H., Misawa, N. 1994. Metabolic engineering for production of beta-carotene and lycopene in Saccharomyces cerevisiae. Biosci Biotechnol Biochem., 58(6):1112-4.
  9. Chen, Y.Y., Shen, H.J., Cui, Y.Y., Chen, S.G., Weng, Z.M., Zhao, M., Liu, J.Z., 2013. Chromosomal evolution of Escherichia coli for the efficient production of lycopene. BMC Biotechnol.  28;13:6. doi: 10.1186/1472-6750-13-6.
  10. Cui, Y.Y., Ling, C., Zhang, Y.Y, Huang, J., Liu, J.Z., 2014. Production of shikimic acid from Escherichia coli through chemically inducible chromosomal evolution and cofactor metabolic engineering. Microb Cell Fact.  Feb 10;13:21. doi: 10.1186/1475-2859-13-21.
  11. Zhu, C.F., Chen, X., Wang, Y.D. 2004. Carotenoid biosynthesis in plants and application of its relative genes in gene engineering. Zhi Wu Sheng Li Yu Fen Zi Sheng Wu Xue Xue Bao, 30(6):609-18.
  12. Schmidt-Dannert, C., 2000  Engineering novel carotenoids in microorganisms. Curr Opin Biotechnol.,  11(3): 255-61.
  13. Tao, J., Zhang, S.L., Xu, C.J., An, X.M., Zhang, L.C., 2002. Gene and gene engineering of carotenoid biosynthesis. Sheng Wu Gong Cheng Xue Bao., 18(3):276-81.
  14. Miura, Y., Kondo, K., Saito, T., Shimada,. H., Fraser, P.D., Misawa, N. 1998. Production of the carotenoids lycopene, beta-carotene, and astaxanthin in the food yeast Candida utilis. Appl Environ Microbiol.  64(4):1226-9.
  15. Viuda-Martos, M., Sanchez-Zapata, E., Sayas-Barberá, E., Sendra, E., Pérez-Álvarez,  J. A.,  Fernández-López. J., 2014. Tomato and Tomato Byproducts. Human Health Benefits of Lycopene and Its Application to Meat Products: A Review. Journal Critical Reviews in Food Science and Nutrition 54(8): 1032-1049.
  16. Misawa, N., Shimada, H., 1997. Metabolic engineering for the production of carotenoids in non-carotenogenic bacteria and yeasts. J Biotechnol., 3;59(3):169-81.
  17. Svelander, C.A., Tibäck, E.A., Ahrné, L.M., Langton, M.I., Svanberg, U.S., Alminger, M.A.J., 2010. Processing of tomato: impact on in vitro bioaccessibility of lycopene and textural properties. Sci Food Agric.  90(10):1665-72.
  18. Colle, I., Lemmens, L., Van Buggenhout, S., Van Loey, A., Hendrickx, M., 2010. Effect of thermal processing on the degradation, isomerization, and bioaccessibility of lycopene in tomato pulp. J Food Sci. Nov-Dec;75(9):C753-9. doi: 10.1111/j.1750-3841.2010.01862.x.

*Contents are provided by Authors of articles. Please contact us if you having any query.






Bank Details