INTERNATIONAL RESEARCH JOURNAL OF SCIENCE ENGINEERING AND TECHNOLOGY

( Online- ISSN 2454 -3195 ) New DOI : 10.32804/RJSET

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SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME NOVEL 1-(1-HYDROXYNAPHTHALENE-2-YL) DERIVATIVES

    3 Author(s):  VISHNUPRIYA JHALA, RENU RATHORE, YUVRAJ KUNWAR JHALA

Vol -  10, Issue- 4 ,         Page(s) : 21 - 27  (2020 ) DOI : https://doi.org/10.32804/RJSET

Abstract

The aim of present work emphasized on designed and synthesize the molecule having naphthalene ring in one of diaryl having isoxazole as pharmacophoric heterocyclic moiety for synthesis of safer anti microbial agents. An convenient procedure has been developed for the synthesis of some novel 1-(1-hydroxy naphthalene-2-yl) derivatives having good yield and their chemical structure were confirmed by IR, 1HNMR and mass spectroscopy. All the compounds were evaluated for antimicrobial activity against various strains of bacteria and fungi. The presence of nitro group at position 5th of isoxazole ring was important for antibacterial activity.

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